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| Gu,X.-D.; Xu,L.-L; Zhao,H.; Gu,J.-Z; Xie,X.-H. |
| As an active constituent of the beetle Mylabris used in traditional Chinese medicine, cantharidin is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays a crucial role in cell cycle progression, apoptosis, and cell fate. The role and possible mechanisms exerted by cantharidin in cell growth and metastasis of breast cancer were investigated in this study. Cantharidin was found to inhibit cell viability and clonogenic potential in a time- and dose-dependent manner. Cell cycle analysis revealed that cell percentage in G2/M phase decreased, whereas cells in S and G1 phases progressively accumulated with the increasing doses of cantharidin treatment. In a xenograft model of breast cancer, cantharidin inhibited tumor growth in a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cantharidin; Breast cancer; ERK/MAPK pathway; Growth; Migration; Invasion. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700608 |
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| Nikbakhtzadeh,M. R.; Ebramihi,B.. |
| Cantharidin is mainly found in the beetle families Meloidae and Oedemeridae (Insecta: Coleoptera) which are the natural producers of this terpene anhydride. Most studies to date have focused on cantharidin distribution in blister beetles, with few reports on recently found cantharidin-related compounds (CRCs). Using gas chromatography-mass spectrometry (GC-MS), the present work reported cantharidin and two CRCs, palasonin and cantharidinimide from Mylabris impressa stillata (Baudi, 1878) which was collected from Toyserkan county, Hamedan Province, Iran. Ionization provided mass spectra with characteristic fragments of cantharidin at m/z 96 and 128, demethylcantharidin at m/z 82 and 114, and cantharidinimide at m/z 70, 96 and 127. This is the first time... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Cantharidin; CRC; Palasonin; Cantharidinimide; Blistering beetle; Meloidae; Mylabris. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300011 |
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| Nikbakhtzadeh,MR; Tirgari,S. |
| This study focused on coleopteran species that are responsible for the emergence of recent cases of dermatological manifestations in Iran. To the best of our knowledge, five species of the family Meloidae and nine species of the genus Paederus are by far the only beetles recognized as medically important in Iran. The staphylinids consists of Paederus ilsae, P. iliensis, P. fuscipes, P. kalalovae, P. balcanicus, P. lenkoranus, P. littoralis, P. carpathicus, P. nigricornis, while the meloids are Mylabris impressa, M. guerini, Muzimes iranicus, Alosimus smyrnensis and Epicauta sharpi. Most cases of linear dermatitis in this country occur in areas bordering the Caspian Sea. This problem is caused by beetles of the genus Paederus which are present as adults... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Meloidae; Staphylinidae; Paederus; Beetle; Dermatitis; Pederin; Cantharidin; Iran. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400004 |
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